Ask A Psychiatrist
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Clozapine: Benefits, Reducing Side Effect Risks, and Alternatives
This is a recorded lecture. It was given at the monthly Psychosis Education Event in January, 2023. The monthly Psychosis Education Event consists of a free lecture on some mental health related topic, followed by an open-forum question/answer session with a psychiatrist and clinical psychologist. It is free of charge and open to the public. If you would like to join, send me a note via askapsychiatrist.info
Clozapine is the most effective medication for schizophrenia. It is the only medication with FDA approval for reducing suicide risk. About 30% of people with schizophrenia do not get significant benefit from standard antipsychotic medication -- yet in that subset of individuals, clozapine is successful in about 50% of cases (the success rate of other antipsychotic medications is about 7% to 14%).
This lecture discusses:
1. Why do some people with schizophrenia-like symptoms not respond to standard, first-line antipsychotic medications?
2. What are the unique advantages of clozapine?
3. What are the most common or worrisome clozapine side effects, and how can their risks be minimized?
4. Are there any alternatives to clozapine?
zhlédnutí: 6 288

Video

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Komentáře

  • @mddell24
    @mddell24 Před dnem

    Ever so slowly the PSYCOs realize they need to get rid of their chemical BS. Just go with non-western lifestyle. It works. So I gave this vid a like - small steps I the right direction, better than bad dogma.

  • @quoderatdemonstrandum5442

    Trazadone just makes me sweat profusely. And thereby get zero sleep. So I stay awake 2 or 3 days at a time. And eventually pass out. But the insurance company won't buy that fact. So I'm stuck with it....

  • @italianlessonsnyc1176

    What if someone has adhd and delusional disorder? What would happen to their dopamine?

  • @evilbarbie2160
    @evilbarbie2160 Před 3 dny

    Having been misdiagnosed with this and drugged as such instead of Complex PTSD from scapegoating and narcissistic abuse, the drugs gave me suicidal thoughts, paranoia, and opened me up to further abuse cycles. i am disgusted with the psychiatric field. Worst drug pushers in the world. Those wearing the whit coats saying lets rewire your brain. Pure torture with no way of getting justice without further trauma. All i can do is hope there is a hell they go to and experience everything they've done to me.

  • @discdoggie
    @discdoggie Před 6 dny

    Trazadone seems safer than gabapentin for sleep and MUCH safer than benzos.

  • @Kingjames313
    @Kingjames313 Před 8 dny

    Cannabis DEFINITELY causes depression….when you run out!

  • @user-qj8pc4dv7g
    @user-qj8pc4dv7g Před 8 dny

    ''ONLY" 50%?

  • @The_AlexK_Project
    @The_AlexK_Project Před 9 dny

    Its normal to feel depresed if you are controlled by a plant. How pathetic must ones life be to get to that point?

  • @areafifty
    @areafifty Před 9 dny

    I've had CHS and have had two episodes. The first one nearly killed me

  • @ladysparkalin420
    @ladysparkalin420 Před 10 dny

    I lost the love of my life, my home and my job due to cannabis induced psychosis. Didn't realize it wasn't paying nice with my psychiatric medications...

  • @jerrybama
    @jerrybama Před 12 dny

    Well I am 72 yr old i been smoking weed since I was 17 i dont see any problem

  • @lluna305
    @lluna305 Před 15 dny

    Day 5 no za ( chronicle chief carts and bud for about 1.5 years ) first days were really bad I think I had early stage of CHS but I recognized it early on and stopped entirely the first couple days were so bad. Like a pain I would never wish on anyone. slowly im getting better and my symptoms are starting to get better but still in the mornings I get sick before I take medicine for the nausea which helps me lots.

  • @AmandaHuginkiss-hn3ox

    Marijuana is neat but for bipolar people it isn't. I found my solution was complete sobriety and a holistic way of life not to mention a stable routine. I'm 35 now and was diagnosed when was 21 it took me years of fuck ups, psych wards, heavy drug dabbling, suicide attempts and TONS of research to finally take it seriously and to finally understand that this requires a certain format. Yeah it might not be fun or exciting but it keeps me on the straight and narrow. Now i feel more aware and resilient than I've felt ever. The quality of my relationships are tremendous and just my quality of life is great. I'm able to work through my depressive episodes and utilize my manic episodes for the betterment of myself and those around me. Don't get me wrong marijuana is a remarkable drug(it's a drug and to argue it isn't is ridiculous lol) with a neat benefits but i know for a fact that i never want to do it again. I've put too much work into this.

  • @crystalthaler4155
    @crystalthaler4155 Před 17 dny

    Im sure i know some people who are going through this. Its really sad. Its a hard process. Hoping theres a treatment for it and these people can get better eventually

  • @abhmmh8892
    @abhmmh8892 Před 20 dny

    This dude sounds like Chad ripperger

  • @user-tp4rj2yw8b
    @user-tp4rj2yw8b Před 20 dny

    Chs feels like fighting death. Iv suffered with this for 21 years . Sweats Cramps Constant vomiting Weight loss Insomnia Drastic weight loss . Starts 24 hours after the last cone . And used to only last three days. Now it lasts 7 and I end up in hospital . With the " medical weed potency I'm very concerned for anyone whom tries to come off as it is up to 25 percent THC as opposed to 2 percent

  • @alanspicer500
    @alanspicer500 Před 20 dny

    Clozapine is the only drug that has fully treated my psychosis I have schizophrenic affective disorder and still suffer from depression I will never stop taking clozapine only issue is discomfort from monthly blood draw you are a cool guy thanks

  • @melindajackson3602
    @melindajackson3602 Před 21 dnem

    Sounds interesting and has reoccurrence

  • @Jay-kk3dv
    @Jay-kk3dv Před 22 dny

    Reduce carbohydrate intake, increase fat and protein. Antipsychotics don’t even treat schizophrenia, they just reduce dopamine, sedating the patient.

  • @brand78100
    @brand78100 Před 22 dny

    Just came across this interview years later after it's been put online. Bethany, if you ever read this comment, you are a blessing. Having the courage to come forward and spread the voice of so many fellow patients, with plain honesty and wit, in public helps all over the world. We must change narratives and overall stigma on these diseases. This keeps killing people, in many different ways. Out of shame or lack of proper medical care. To people reading this comment, never feel ashamed to get help and try clozapine, if other medications have failed. It can life-changing, as it did to me. Don't listen to this idea that clozapine would only be prescribed to resistant patients, other medications just don't work on the many other neurological and biological pathways that have been identified as faulty in this disease. And maybe new treatments will fill that void in a near future.

  • @aneyesky
    @aneyesky Před 23 dny

    I see disregulation in sports every day. Hit a home run in the 4th inning of a 10-1 game, and the player tosses the bat, screams, pimps his home run all the way around the bases. Look at how Spacex in their live feeds in the audience,reacts to a positive launch experience as well. Screaming at the top of their lungs while flailing their arms in the air. Strictly from a scientific POV, I’m curious if this is normal. “Normal”

  • @elleschraufek4644
    @elleschraufek4644 Před 25 dny

    Akathesia from being ct off klonipin. Six years of torment!

  • @Fedaalis
    @Fedaalis Před 26 dny

    I am 39 and diagnosed BP 1 with psychotic features. I do take lithium as a mood stabilizer. Let me preface this by saying that I understand that everyone has different brain chemistry & some drugs that are good for one person might be ill advised for another. Anyway cannabis is very effective in treating bipolar for me. Particularly anxiety and depression. I would note that 'isolates' and alt-cannabinoids may not necessarily make things worse, but they do not help with anxiety as much as fully intact cannabis flower with all of its natural ratios of cannabinoids and terpenes. I experience no increase in psychotic symptoms and it has not yet induced a psychotic episode. Nor does it seem to induce mania.

  • @hannahowen1801
    @hannahowen1801 Před 28 dny

    This would explain also why autistic folks are more prone to developing psychosis, due to the excess glutamate.

  • @karam7328
    @karam7328 Před 29 dny

    Absolute hell! My body is incredibly weak from the constant need to pace. Muscles in spasm from trying to stay still. Propranolol and Klonopin barely working anymore. Going on 6 weeks. Took Latuda but only for a few weeks. Soon I will need help getting around, Can not drive anymore. Will this ever end? Hoping it's not chronic but am starting to loose hope. Should be improving by now!! Hand tremor also present. Might this be something else besides medicine induced akathisia? Neurologists and psychiatrists are not coming up with answers! Please make it stop!

  • @kraytas9762
    @kraytas9762 Před měsícem

    So basically not enough research and everyone in the comments largely disagree😅

  • @sylviadominguez8327
    @sylviadominguez8327 Před měsícem

    RESTLESSNESS IS PUTTING IT LIGHTLY... on the side effects they need to replace restlessness with Akathisia!!

  • @pancanman
    @pancanman Před měsícem

    Been taking it for 30 years. I don't think that it does anything. No difference in my asthma, no difference in my mood. I have skipped doses many times by accident, but that also had no effect. Everyone is different. Why do I keep taking it? Habit.

  • @anthonyadonis9386
    @anthonyadonis9386 Před měsícem

    Try our niacine vitamin b3 and L theanine it helps relieve symptoms.

  • @Awesomes007
    @Awesomes007 Před měsícem

    Calling akathesia restlessness is like calling torture tickling.

  • @WockhardtPint
    @WockhardtPint Před měsícem

    Wassam bro you prolly going through it right now(whoever you are) visualizing thoughts that you've never thought or hearing things that you would never say in your head, like how i was. THE CURE IS TO STRENGTHEN YOUR PREFRONTAL COREX. For 3 years i searched for info and couldn't find anything until i studied more on the brain, until i found out, You have to strengthen your prefrontal cortex because that's the main part of your brain that keeps you intrigued in conversation, grounded on what your doing and where your at, and your memory. Your mind is moving so fast that your brain cant catch up with it, and you just lost alot of your intelligence and when i say lost i dont mean its deleted, i mean you have to shine light on it and grow it back to the way it was previously before and thats just the real. You gone be good mane just do these things. FOODS: Drink milk(helps develop mind), eat berries (they are antioxidants if you were laced or smoked some bad weed think of Lysol on germs) Eat fish (the fat in fish grows your grey matter) Nuts (builds brain protection). PHYSICAL THINGS: exercise( bball soccer or anything like that) Watch informational videos (ones you used to watch as a kid about things such as time, geography, shapes, colors, and distance THE BASICS FIRST) Copy and write from textbooks(word for word). Think of your brain as a above ground pool and the water inside is all of your brains knowledge, then out of nowhere something pops it and now you have to batch the pool and fill it back up with information. Dont look at this as a step back learn from this bro and do what i said because i didnt have anyone tell me this i had to fight this shit for 3 years im talking bout fucked up couldn't get my mind right to chase 100 racks but now im good cuz i beat it from doing all that and if i can beat this shit you can to nigga. If you real go copy and paste this so other people could get straight too. *Go get a $million and ALMSOT DONT COUNT NIGGA*

  • @Noname-hs5lx
    @Noname-hs5lx Před měsícem

    Can you learn at 45 if in therapy for five years already so ready

  • @Borispirit
    @Borispirit Před měsícem

    I experienced twice in my life substance withdrawal psychosis from marijuana. Both episodes drastically changed my life. I my grandfather was a schizophrenic and I was eventually diagnosed from schizophrenic to schizoaffective.. long story short I asked god to help me I didn’t know why I asked but eventually I got totally sober and my paranoid delusional thoughts have evaporated for the most part. To anyone struggling with addiction or mental ilness: you are worthy of having a good life I’m living proof that you can.. 4 years and counting.. 🙏❤️

  • @NilsExp
    @NilsExp Před měsícem

    I'm rockin Invega Trinza (3mo shot in the b&tt cheek), finally something that works

  • @vaccaphd
    @vaccaphd Před měsícem

    It was the worst experience of my life.

  • @mistervacation23
    @mistervacation23 Před měsícem

    A young lady I know, let's call her Elaine, happened to find herself overwhelmed with feelings of resentment and hostility for her friend, let's call him George. She felt that George was somewhat of a loser and that she was the one who deserved to be married first. She also happened to mention to me that her friend had wondered if going to a prostitute while you're engaged is considered cheating. His feeling was they're never going to see each other again so what's the difference?

  • @tristanbulluss9386
    @tristanbulluss9386 Před měsícem

    I use thc for my schizophrenia.

  • @elinordrake9716
    @elinordrake9716 Před měsícem

    Really interesting, thanks!

  • @benzapp1
    @benzapp1 Před měsícem

    This is a dirty secret not often discussed. Also I wonder if Japan has a better system to test new drugs versus existing drugs. Placebo control alone should just be one step.

  • @absm5186
    @absm5186 Před měsícem

    I can confirm and attest to this. I stopped just in time, i was clearly demonstrating signs of physchosis induced by cronic cannabis use. I was mixing with tabbacco in spliffs. Smoked for 1 years morning to night and had i not quit i belive my life would have been very different. The withdrawals and pannick attacks after i stopped only confirm this. You can believe it and take heed or you can carry on using smoking away your body and life till you reach that stage of mental health issues. F around and findout like i did.

  • @justserv
    @justserv Před měsícem

    Benzodiazapines can help, but going off them too fast can actually cause it. That's how Jordan Peterson got it, from what I understand.

  • @karayursa
    @karayursa Před měsícem

    nicotine is not bad for ocd and schizophrenia! But cannabis is the death penalty for schizophrenic and ocd people

  • @j.kelsey9926
    @j.kelsey9926 Před měsícem

    B6 for the win

  • @kwokw8992
    @kwokw8992 Před měsícem

    I take trazodone for many years for sleep. Is it safe to continue. Will it related to dementia

  • @raymondspilker7466
    @raymondspilker7466 Před měsícem

    You should be ashamed!

  • @tonyabroughton2531
    @tonyabroughton2531 Před měsícem

    I believe it helps with pain appetite but not for everyone but some🦋🌈

  • @tonyabroughton2531
    @tonyabroughton2531 Před měsícem

    1st time watching see my connection💯

  • @cherylstewart8633
    @cherylstewart8633 Před měsícem

    HOW DO PEOPLE WITH DELUSIONAL DISORDER GET ON DISABILITY OR GET HOSPITALIZED OR EVEN GET TREATMENT SINCE THIER DELUSIONS DISALOW THEM FROM ADMITTING TO BEING DELUSIONAL AND SO DO NOT ACCEPT TREATMENT??

  • @michelle77345
    @michelle77345 Před měsícem

    Pepsid, capssasin cream rubbed on tummy. Stop using.

  • @michelle77345
    @michelle77345 Před měsícem

    When I am nausea I feel like I'm gonna die If I don't get an iv. Waited 4 days before I went to er. Spent 3 days getting better.