Myelodysplastic Syndromes include a group of clonal disorders of hematopoietic stem cells characterized by bone marrow failure in association with dysplastic cell morphology in one or more cell lineages.
A hallmark of these diseases is simultaneous proliferation and apoptosis of hematopoietic cells (ineffective hematopoiesis), leading to the paradox of a hypercellular bone marrow but pancytopenia in peripheral blood.
There is a tendency for MDS to progress to acute myeloid leukemia (AML).
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