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Selective non-toxic pyrrolo[1,2-a]quinoxalines as therapeutic agents to treat Alzheimer's Disease
This is a pre-recorded presentation that is part of the 5th London Metropolitan University Student and Staff Research Conference: 'Past - Present - Future'. The conference takes place across the 2nd and 3rd July 2024.
'Design of selective non-toxic pyrrolo[1,2-a]quinoxalines as therapeutic agents for the treatment of Alzheimer's Disease' by Margarita Damai
Every four seconds a new patient is diagnosed with Alzheimer’s Disease (AD) and 7.7 million new cases are reported annually worldwide. AD is a progressive neurodegenerative form of dementia characterised by cognition decline. The leading cause of AD is the amyloid and tau proteins built up among brain cells, which prevents intercellular communication. Inevitably this affects memory and impairs essential physiological functions. Alarmingly, cases are predicted to increase up to 145 million by 2050 worldwide.
As a growing epidemic, AD imposes a financial burden globally with annual costs of over £818 billion. Scientists have tried to find a cure since its discovery in 1906. Current treatments either target amyloid proteins or temporarily slow AD progression. AD is manifested by abnormally low levels of acetylcholine (ACh), a neurotransmitter used for intercellular communication. Acetylcholinesterase enzyme (AChE) breaks down Ach; thus, inhibiting its activity can prevent Ach reduction.
Our project aimed to synthesise six pyrrolo[1,2-a]quinoxalines analogues as potential AChE inhibitors. This project presents a novel approach to using thiols as an alternative to tin, which is toxic and, based on the literature, is the most preferred method. The compounds were assayed, with some showing low toxicity and excellent selectivity to AChE. According to recent studies, sulaquinoxaline, which is toxic, can massively eliminate amyloid proteins. Therefore, less toxic analogues are suggested as an alternative, including the pyrrolo[1,2-a]quinoxalines series we designed. Consequently, further steps involve testing our compounds to determine if they can reduce amyloid plaques.
#londonmetresearch
#LMUpastpresentfuture2024
#alzheimers
#neurodegenerative
#syntheticchemistry
londonmet.ac.uk/research
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zhlédnutí: 13

Video

Leveraging Data-Driven Approach to Empower Assistive Technology
zhlédnutí 19Před 16 hodinami
This is a pre-recorded presentation that is part of the 5th London Metropolitan University Student and Staff Research Conference: 'Past - Present - Future'. The conference takes place across the 2nd and 3rd July 2024. 'Leveraging Data-Driven Approach to Empower Assistive Technology' by Sabin Nakarmi Assistive technology refers to tools, devices or software that aid in the learning experience of...
Mapping psychotherapeutic elements within prenatal classes
zhlédnutí 20Před 16 hodinami
This is a pre-recorded presentation that is part of the 5th London Metropolitan University Student and Staff Research Conference: 'Past - Present - Future'. The conference takes place across the 2nd and 3rd July 2024. 'Mapping psychotherapeutic elements within prenatal classes and understanding psychotherapists’ viewpoints on both the prenatal period and prenatal classes' by Jemima Atar Aim of ...
Exploring the Art-Making Process of Dyslexic Artists through the Lens of the Sublime
zhlédnutí 25Před 19 hodinami
This is a pre-recorded presentation that is part of the 5th London Metropolitan University Student and Staff Research Conference: 'Past - Present - Future'. The conference takes place across the 2nd and 3rd July 2024. 'The Dyslexic Sublime: Exploring the Art-Making Process of Dyslexic Artists through the Lens of the Sublime' by Skye William Eade This study explores the coaction between dyslexia...
Permittivity-Based Glucose Monitoring and the Development of Non-Invasive Sensors
zhlédnutí 43Před 19 hodinami
This is a pre-recorded presentation that is part of the 5th London Metropolitan University Student and Staff Research Conference: 'Past - Present - Future'. The conference takes place across the 2nd and 3rd July 2024. 'Analysis of the Accuracy of Permittivity-Based Glucose Monitoring and Its Consequences for the Development of Non-Invasive Sensors' by Saksham Arora Diabetes has a global impact ...
Iconography of glocal visual production and social movements in Hong Kong
zhlédnutí 10Před 19 hodinami
This is a pre-recorded presentation that is part of the 5th London Metropolitan University Student and Staff Research Conference: 'Past - Present - Future'. The conference takes place across the 2nd and 3rd July 2024. 'Iconography of glocal visual production and social movements in Hong Kong' by Hoyee Tse My talk will focus on my doctoral research about the visual production of Hong Kong. Consi...
An investigation into the legality of white phosphorus uses in the military
zhlédnutí 13Před 19 hodinami
This is a pre-recorded presentation that is part of the 5th London Metropolitan University Student and Staff Research Conference: 'Past - Present - Future'. The conference takes place across the 2nd and 3rd July 2024. 'An investigation into the legality of White phosphorus uses in the military and the consequences to human health and the environment: Should White phosphorus be classed as an inh...
Pilot Study: Lessons Learnt and Next Steps
zhlédnutí 24Před 19 hodinami
This is a pre-recorded presentation that is part of the 5th London Metropolitan University Student and Staff Research Conference: 'Past - Present - Future'. The conference takes place across the 2nd and 3rd July 2024. 'Pilot Study: Lessons Learnt and Next Steps' by Mareen Ruwandi Perera My research explores the role of unlearning in developing lecturer identity among part-time higher education ...
Reflecting on Early Career Academics’ Experiences of Sexual Harassment and Gender-Based Violence
zhlédnutí 28Před 19 hodinami
This is a pre-recorded presentation that is part of the 5th London Metropolitan University Student and Staff Research Conference: 'Past - Present - Future'. The conference takes place across the 2nd and 3rd July 2024. '“Bullets in their heads”: Reflecting on Early Career Academics’ Experiences of Sexual Harassment and Gender-Based Violence' by Eleni Meletiadou Despite increased research on sexu...
Enabling digital transformation and sustainability via the use of AI-powered learning tools
zhlédnutí 19Před 19 hodinami
This is a pre-recorded presentation that is part of the 5th London Metropolitan University Student and Staff Research Conference: 'Past - Present - Future'. The conference takes place across the 2nd and 3rd July 2024. 'Enabling digital transformation and sustainability via the use of Artificial Intelligence-powered learning tools and mobile assisted learning: Towards inclusive education in busi...
The Inner Life of a Born-Global Family Firm: A Longitudinal Study of Organisational Change
zhlédnutí 11Před 19 hodinami
This is a pre-recorded presentation that is part of the 5th London Metropolitan University Student and Staff Research Conference: 'Past - Present - Future'. The conference takes place across the 2nd and 3rd July 2024. 'The Inner Life of a Born-Global Family Firm: A Longitudinal Study of the Effects of Organisational Change on Internal Social Capital' by Bettina Coleman-Schoels Family firms are ...
Capturing the Participants' Voice
zhlédnutí 13Před měsícem
This is a recording from a seminar titled 'Capturing the Participants’ Voice: Using Causal Mapping supported by Group Decision Software to enhance Procedural Justice', part of a series from the Performance with Purpose Research Centre at London Metropolitan University. 23 April 2024 In this seminar Dr Parmjit Kaur discussed her work, which examines how a causal mapping (soft operational researc...
Career Upskilling Series: Reviewing for Journals
zhlédnutí 7Před 2 měsíci
This is a recording from a seminar titled 'Career Upskilling Series: Reviewing for Journals', the first in a series from the Performance with Purpose Research Centre at London Metropolitan University. 8 March 2024 In this talk, we discussed the role of a Reviewer for academic peer-reviewed journals. Doris Schedlitzki shared her insights - as a Reviewer and Journal Editor - on the review process...
Public and Patients Involvement and Engagement in Research
zhlédnutí 15Před 2 měsíci
This is a recording of a seminar titled 'Public and Patients Involvement and Engagement in Research: sharing examples and practices' hosted by the Centre for Primary Health and Social Care at London Metropolitan University. 27 March 2024 The session was led by Dr Anastasiya Kichigina, Senior Research Programme Manager (NIHR) and Senior Lecturer in Public Policy and Health (London Metropolitan U...
'Schrödinger's Homophobia is alive and dead': Doublethink in the Log Cabin Republicans
zhlédnutí 67Před 3 měsíci
This is a recording of a seminar titled ''Schrödinger's Homophobia is alive and dead': Doublethink in the Log Cabin Republicans' hosted by Gender and Sexual Diversities Research Group of the Global Diversities and Inequalities Research Centre at London Metropolitan University. 18 March 2024 The term 'doublethink' was coined by George Orwell in his seminal novel Nineteen Eighty-Four. It concerns...
The educational experiences of young refugees in Bangkok, Thailand
zhlédnutí 53Před 3 měsíci
The educational experiences of young refugees in Bangkok, Thailand
7th Annual Interdisciplinary Health and Wellbeing Research Conference
zhlédnutí 42Před 4 měsíci
7th Annual Interdisciplinary Health and Wellbeing Research Conference
Role of Imprinting in Sustainable Business Model Innovation: A Study of an Emerging Country Startup
zhlédnutí 78Před 4 měsíci
Role of Imprinting in Sustainable Business Model Innovation: A Study of an Emerging Country Startup
Reconfiguring healthcare supply chains: scope, challenges and opportunities
zhlédnutí 8Před 4 měsíci
Reconfiguring healthcare supply chains: scope, challenges and opportunities
Inaugural lecture: Physis in a Changing World' - Nature’s Enigma - Prof. Nick Temple
zhlédnutí 655Před 5 měsíci
Inaugural lecture: Physis in a Changing World' - Nature’s Enigma - Prof. Nick Temple
'It’s my diabetes': Children and young people lived experiences
zhlédnutí 18Před 6 měsíci
'It’s my diabetes': Children and young people lived experiences
Latin American LGBTQ+ migrants in London, an invisible population.
zhlédnutí 63Před 6 měsíci
Latin American LGBTQ migrants in London, an invisible population.
Decentering the 1969 Stonewall Riots: One Foundational Myth for Global LGBTQ Communities or many?
zhlédnutí 94Před 7 měsíci
Decentering the 1969 Stonewall Riots: One Foundational Myth for Global LGBTQ Communities or many?
Interdisciplinary Research Forum: Architecture Beyond Buildings
zhlédnutí 41Před 7 měsíci
Interdisciplinary Research Forum: Architecture Beyond Buildings
Self-management by older people living with cancer and multi-morbidity
zhlédnutí 21Před 7 měsíci
Self-management by older people living with cancer and multi-morbidity
From Panel to Dynamic Panel Data Models: What, Where, When and How?
zhlédnutí 54Před 7 měsíci
From Panel to Dynamic Panel Data Models: What, Where, When and How?
To whom does memorialisation/memory speak? Image and the Uncanny in Cases of Historical Violence
zhlédnutí 20Před 7 měsíci
To whom does memorialisation/memory speak? Image and the Uncanny in Cases of Historical Violence
Pharmacists as clinicians: past, present and future
zhlédnutí 29Před 8 měsíci
Pharmacists as clinicians: past, present and future
Predictors of early initiation of breastfeeding & duration of breastfeeding among SouthAfrican women
zhlédnutí 83Před rokem
Predictors of early initiation of breastfeeding & duration of breastfeeding among SouthAfrican women
Selective Prioritisation of Real-Time IP Packets to Improve QoS in 5GWireless Sensor Networks
zhlédnutí 263Před rokem
Selective Prioritisation of Real-Time IP Packets to Improve QoS in 5GWireless Sensor Networks

Komentáře

  • @k.s783
    @k.s783 Před 5 dny

    The question regarding a potential kinship between Romani Finns and Swedish Finns doesn’t make a lot of sense mainly because the Romani have a completely different ethnic, language and cultural background than Swedish speaking Finns who are native to Finland. Historically speaking the Romani are a new group of immigrants compared to Swedish speaking Finns who aren’t even considered immigrants. The Romani aren’t historically Swedish nor Finnish speakers, which is different compared to Swedish Finns whose first language is Swedish. Romani are a distinct people with their own language and cultural history. The question regarding a “kinship” doesn’t seem genuine or serious, but was rather an attempt to disqualify the research and minimize some of the negative experiences of Swedish speakers in Finland.

  • @hobknob1437
    @hobknob1437 Před 7 dny

    Except the english kicked people off their own land, then claimed it was now England. The peoples you mentioned, with the possible exception of the sami, aren't from Sweden, or any of the nordic lands.

  • @chanpreet4490
    @chanpreet4490 Před měsícem

    Very nice explanation

  • @sarvothamanbhimasenarao2263

    From the diagram provided, Schizophrenia is on one side and the addiction ( schizoidal masturbation? ) is on the other side. Does it correlate with the fact that Schizoid disorder is a spectrum disorder?

  • @elplebe1762
    @elplebe1762 Před 2 měsíci

    Since frequencies like beta, thelta, delta etc affect the brain. What frequency would have effects on the region of the brain that deals with addictions?

  • @AnkitAggarwalrrr
    @AnkitAggarwalrrr Před 2 měsíci

    Ankit Aggarwal from India 🇮🇳 watching(11 april2024)

  • @DaleIvester-ik8qe
    @DaleIvester-ik8qe Před 5 měsíci

    You haven't thought it out correctly but what would i know. You keep trying and maybe you will accomplish your goals but I already know

  • @scarletgray1
    @scarletgray1 Před 9 měsíci

    Listen to me. I’m so sick of people that only know about addiction from text books. People wouldn’t even go down the road of drugs and secretive actions if they didn’t feel so disconnected and so I hopeful of there future as young people. And 99% of people with addictions suffered trauma that was sexual paedophilia. And no one is talking about the fact that community makes it impossible to get clean and get good jobs etc cos ur forever stopped by criminal history.

  • @thistree9028
    @thistree9028 Před 9 měsíci

    Thank you! Fascinating work and discussion. One thing that wasn’t mentioned is how traumatic experience, especially if chronic in childhood, can change the brain and how this can possibly lead to later in life addictions. How does abuse change the physiology of the brain to pre dispose? Are there similarities in brain function? Etc..Would be hard to do a study on though. Where to get a control group of traumatized kids?.. I’d think ethics would be an issue..

  • @Madhisco
    @Madhisco Před 10 měsíci

    Intriguing research.

  • @jackgregory7997
    @jackgregory7997 Před rokem

    Promo>SM ✅

  • @___unknown_x_
    @___unknown_x_ Před rokem

    Nixe...

  • @peterwilson5528
    @peterwilson5528 Před rokem

    The second official language in Finland is Swedish still. How can a Finnish government switchboard have an operator for the Finnish Legal Aid office that cannot speak the second official language at all? Unless it is a deliberate Finnish government policy against the Finnish Swedes? Since the legal matter will be totally in Swedish how the f**k is it possible the law system is unable to properly protect the rights of an official minority group. It's already been a nightmare to get capable Swedish lawyers or service personnel. Swedish Finns are an endangered species in Finland. The day they removed Swedish as a compulsory language in the schools they announced that it is open season for Swedish Finn's rights. In Finland Gypsies, Russians, Sami, and Somali are all persecuted minorities. The English did the same in Ireland with the Irish language when they had it, and in Scotland with Gaelic.

  • @HomeAtLast501
    @HomeAtLast501 Před rokem

    Fame is being well-known, celebrity is being well-known, as well as celebrated, revered, held in high regard.

  • @HomeAtLast501
    @HomeAtLast501 Před rokem

    First lady who introduced discussion needs to get a microphone. It's 2023.

  • @samanthakoch4722
    @samanthakoch4722 Před rokem

    *promo sm*

  • @thaotaylor6669
    @thaotaylor6669 Před 2 lety

    Will the Government implement this UBI, they are just too hard up, they said make work paid yeah, and you paid for every last bill, you end up being poor again, when cost of living is rising. people will be restrict their spending, with Universal basic income people will be able treat themselves.

  • @sarakhalil5152
    @sarakhalil5152 Před 2 lety

    Can i get a script for these interview plz?